Acyclovir Bioavailability in Human Skin
نویسندگان
چکیده
منابع مشابه
Failure of topical acyclovir in ointment to penetrate human skin.
Topical acyclovir (ACV) in polyethylene glycol (PEG) ointment has been disappointing in the treatment of recurrent herpes simplex virus infections in immunocompetent patients. To investigate the possible role of poor drug delivery from this formulation, we studied the penetration of ACV through excised human skin from three vehicles; PEG ointment, modified aqueous cream, and dimethyl sulfoxide....
متن کاملhplc determination of acyclovir in human serum and its application in bioavailability studies
a sensitive, accurate and rapid reverse phase hplc method was described to quantitate levels of acyclovir in human plasma. the drug, internal standard (metronidazole) and phosphate buffer (0.05 m) were added to serum samples and vortexed for 30 sec. a mixture of isopropyl alcohol:dichloromethane (60:40) was then added and vortexed for 3 min. samples were centrifuged and the supernatant layer wa...
متن کاملHPLC determination of acyclovir in human serum and its application in bioavailability studies
A sensitive, accurate and rapid reverse phase HPLC method was described to quantitate levels of acyclovir in human plasma. The drug, internal standard (metronidazole) and phosphate buffer (0.05 M) were added to serum samples and vortexed for 30 sec. A mixture of isopropyl alcohol:dichloromethane (60:40) was then added and vortexed for 3 min. Samples were centrifuged and the supernatant layer wa...
متن کاملApproaches for Enhancing the Bioavailability of Acyclovir: a Critical Review
Acyclovir, a purine nucleoside analogue, is a promising antiviral compound effective against Herpes Simplex Virus (HSV), Varicella-Zoster Virus (VZV), Epstein-Barr virus (EBV), and Cytomegalovirus (CMV). From the past 3 decades, it has been extensively exploited by the scientists for the diseases caused by these infective viruses. Upto a certain extent they are able to make dosage forms which c...
متن کاملQuantification of uptake and clearance of acyclovir in skin layers.
BACKGROUND Quantification of drug uptake and clearance in the skin layers could provide better insight into the skin kinetics of dermatological formulations aimed for deeper skin tissues. This study assessed the skin kinetics of acyclovir in different skin layers following topical application on the abdominal region of Wistar rats. METHODS In vivo skin pharmacokinetics parameters were determi...
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 1992
ISSN: 0022-202X
DOI: 10.1111/1523-1747.ep12456948